hTERT is a Wnt pathway target gene
نویسندگان
چکیده
Background: Telomerase up-regulation is found in about 90% human cancer specimens and contributes actively to carcinogenesis. Results: β-catenin/TCF4 plays an important role in telomerase activation. Conclusion: hTERT is a direct transcriptional target of the Wnt/β-catenin pathway. Significance: Identifying the function of Wnt/β-catenin pathway in telomerase regulation provides better insight into understanding the role of Wnt pathway in carcinogenesis.
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تاریخ انتشار 2012